Our research aims at elucidating the genetic mechanisms leading to gastrointestinal (GI) disease. We study IBD, IBS and other GI conditions, and strive to identify risk genes and variants through genetic, computational and functional genomic approaches. We also study how the genetic make-up of the host affects the composition of the gut microbiome. We focus on correlating genomic and metagenomic variation with human GI function and disease.
The sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition.
Female-specific Association Between Variants on Chromosome 9 and Self-reported Diagnosis of Irritable Bowel Syndrome.
Increased Prevalence of Rare Sucrase-isomaltase (SI) Pathogenic Variants in IBS Patients.
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.
Faecal microbiota composition associates with abdominal pain in the general population.